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Journal: Scientific reports
Article Title: Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing.
doi: 10.1038/s41598-025-95968-x
Figure Lengend Snippet: Fig. 2. XAV939 treated mice exhibit auditory response deficits. (a) Schematics of head-fixed behavioral training. Elements located inside a soundproof box are positioned within the dashed box. Image was created in BioRender. Merkler, M. (2025) https://BioRender.com/a37u531. (b) Timeline of events in the auditory detection task. Trial starts with the sound onset. If the mouse licks during the response window (lasting 1 s), the sound turns off and water reward is delivered. (c) Diagram of possible events and outcomes during an auditory detection task session. (d) Comparison of training time the mice needed to pass each of the 3 phases in the behavioral assessment. (e) Comparison of d’ between control and treated mice across sound intensities (n = 11 vs. 16 mice; 1 session per mouse). (f) Comparison of reaction time between control and treated mice across sound intensities (n = 11 vs. 16 mice; 1 session per mouse). Error bars indicate SEM; *p < 0.05, **p < 0.01; t-test (d), two-way ANOVA (e and f).
Article Snippet: Apparatus A custom-made behavioral apparatus was located in a
Techniques: Comparison, Control
Journal: Scientific Reports
Article Title: Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing
doi: 10.1038/s41598-025-95968-x
Figure Lengend Snippet: XAV939 treated mice exhibit auditory response deficits. ( a ) Schematics of head-fixed behavioral training. Elements located inside a soundproof box are positioned within the dashed box. Image was created in BioRender. Merkler, M. (2025) https://BioRender.com/a37u531 . ( b ) Timeline of events in the auditory detection task. Trial starts with the sound onset. If the mouse licks during the response window (lasting 1 s), the sound turns off and water reward is delivered. ( c ) Diagram of possible events and outcomes during an auditory detection task session. ( d ) Comparison of training time the mice needed to pass each of the 3 phases in the behavioral assessment. ( e ) Comparison of d’ between control and treated mice across sound intensities ( n = 11 vs. 16 mice; 1 session per mouse). ( f ) Comparison of reaction time between control and treated mice across sound intensities ( n = 11 vs. 16 mice; 1 session per mouse). Error bars indicate SEM; * p < 0.05, ** p < 0.01; t -test ( d ), two-way ANOVA ( e and f ).
Article Snippet: Head-fixed, awake mice were sat in a restraining tube within a
Techniques: Comparison, Control